
L-Pyroglutamic Acid (L-PGA) is a chiral non-protein amino acid derived from glutamic acid, appearing as a white crystalline powder (molecular formula: C₅H₇NO₃). It acts as a key intermediate in peptide synthesis and exhibits bioactive properties, including neuroprotection, antioxidant effects, and moisture retention. XJESON’s synthetic L-PGA powder eliminates risks associated with natural extraction (e.g., inconsistent purity from plant sources like Gastrodia elata 2) and delivers ≥99.5% HPLC-verified purity, complying with USP/EP standards for global pharmaceutical and nutraceutical use.
1. Pharmaceutical raw materials
2. Health care material Formulations
3. Cosmetics materials
4. Agricultural Bio-Stimulants
Parameter |
Specification |
Compliance |
Purity |
≥99.5% (HPLC) |
USP/EP, ICH Q7 |
Optical Purity |
Enantiomeric ratio ≥99:1 |
Chiral GC |
Melting Point |
160–163°C |
ISO 6320 |
Heavy Metals |
<10 ppm |
ICH Q3D |
Endotoxins |
<0.1 EU/mg (on request) |
Injectable-grade option |
Solubility |
Soluble in ethanol/alkali; insoluble in water |
Optimized for encapsulation |
Market-Driven Applications & Case Studies
Industry |
Use Case |
XJESON Solution |
Efficacy Data |
Pharma |
Rongliflozin cocrystal purification |
Coformer-Induced Purification (CoIP) |
Purity >99.8% 6 |
Nutraceuticals |
Cognitive health capsules |
99.5% powder + bacopa extract blend |
34% memory improvement (rat models) |
Cosmetics |
Hyaluronic acid-boosting serum |
1.5% L-PGA in nano-emulsion |
48% hydration increase (in vivo) |
Agriculture |
Bio-fertilizer for rice/paddy crops |
100 ppm LY9 fungal synergist |
125% tillering increase 7 |
Q1: Can L-PGA powder be used in injectable drugs?
A: Yes. XJESON offers endotoxin-controlled (<0.1 EU/mg) L-PGA suitable for parenteral formulations. Full DMF support included.
Q2: Why choose synthetic over natural L-PGA?
A: Synthetic L-PGA ensures batch consistency, eliminates plant-derived contaminants (e.g., pesticides in Gastrodia elata 2), and reduces costs by 25%.
Q3: Is L-PGA effective in NAFLD nutraceuticals?
A: Yes. At 300 mg/day, it reduces hepatic oxidative stress and synergizes with silymarin.
Q4: How to handle bulk L-PGA for stability?
A: Store below -20°C in vacuum-sealed bags. Avoid moisture/light exposure. XJESON provides validated storage protocols.
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