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L-Pyroglutamic Acid

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Product details

What is L-Pyroglutamic Acid Powder?

L-Pyroglutamic Acid (L-PGA) is a chiral non-protein amino acid derived from glutamic acid, appearing as a white crystalline powder (molecular formula: CHNO). It acts as a key intermediate in peptide synthesis and exhibits bioactive properties, including neuroprotection, antioxidant effects, and moisture retention. XJESON’s synthetic L-PGA powder eliminates risks associated with natural extraction (e.g., inconsistent purity from plant sources like Gastrodia elata 2) and delivers ≥99.5% HPLC-verified purity, complying with USP/EP standards for global pharmaceutical and nutraceutical use.

 

L-Pyroglutamic Acid (5)

 


Key Benefits & Applications

 1. Pharmaceutical raw materials

  • Neuroprotective Drug Synthesis:
    • Serves as a critical building block for SGLT-2 inhibitors (e.g., Rongliflozin cocrystals in diabetes therapy 6) and anti-epileptic agents.
    • Mechanism: Modulates GABAergic pathways to reduce neuronal excitability.
  • Antibiotic & Anti-Inflammatory Agents:
    • Intermediate for antibiotics (e.g., ceftibuten) and NSAIDs. Dosage forms: Tablets, injectables (endotoxin <0.1 EU/mg).

2. Health care material Formulations

  • Cognitive Health Supplements:
    • Enhances memory and neuroprotection at 250–500 mg/day doses. Combined with bacopa monnieri for synergistic effects.
    • Clinical relevance: Reduces oxidative stress in hippocampal neurons (search growth: 120% for "cognitive health" keywords).

3. Cosmetics materials

  • Anti-Aging & Moisturizing Agent:
    • Boosts hyaluronic acid synthesis and keratinocyte hydration. Used in serums (0.5–2% concentration) and creams.
    • Market trend: Aligns with "Clean Beauty" demand (30% CAGR in natural cosmetics 1).

4. Agricultural Bio-Stimulants

  • Plant Growth Enhancer:
    • Upregulates nitrogen metabolism genes (e.g., Os01g0322700 by 119x) and increases chlorophyll synthesis (3.2x higher in rice trials 7).

Technical Specifications (XJESON L-PGA Powder)

Parameter

Specification

Compliance

Purity

≥99.5% (HPLC)

USP/EP, ICH Q7

Optical Purity

Enantiomeric ratio ≥99:1

Chiral GC

Melting Point

160–163°C

ISO 6320

Heavy Metals

<10 ppm

ICH Q3D

Endotoxins

<0.1 EU/mg (on request)

Injectable-grade option

Solubility

Soluble in ethanol/alkali; insoluble in water

Optimized for encapsulation


Market-Driven Applications & Case Studies

Industry

Use Case

XJESON Solution

Efficacy Data

Pharma

Rongliflozin cocrystal purification

Coformer-Induced Purification (CoIP)

Purity >99.8% 6

Nutraceuticals

Cognitive health capsules

99.5% powder + bacopa extract blend

34% memory improvement (rat models)

Cosmetics

Hyaluronic acid-boosting serum

1.5% L-PGA in nano-emulsion

48% hydration increase (in vivo)

Agriculture

Bio-fertilizer for rice/paddy crops

100 ppm LY9 fungal synergist

125% tillering increase 7


XJESON Quality Assurance

  • Traceability: Batch-specific COA with HPLC, MS, NMR, and residual solvent reports.
  • Stability: 36-month shelf life at -20°C; potency retention >98.5%.
  • Customization:
    • Particle size: 50–200 μm (direct compression) or <50 μm (enhanced bioavailability).
    • Purity: 98%, 99%, 99.5%, or custom grades.

FAQs for B2B Clients

Q1: Can L-PGA powder be used in injectable drugs?

A: Yes. XJESON offers endotoxin-controlled (<0.1 EU/mg) L-PGA suitable for parenteral formulations. Full DMF support included.

Q2: Why choose synthetic over natural L-PGA?

A: Synthetic L-PGA ensures batch consistency, eliminates plant-derived contaminants (e.g., pesticides in Gastrodia elata 2), and reduces costs by 25%.

Q3: Is L-PGA effective in NAFLD nutraceuticals?

A: Yes. At 300 mg/day, it reduces hepatic oxidative stress and synergizes with silymarin.

Q4: How to handle bulk L-PGA for stability?

A: Store below -20°C in vacuum-sealed bags. Avoid moisture/light exposure. XJESON provides validated storage protocols.

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3 year
Address: Xian, China


Main Product: Furit & Vegetable Powder, Cosmetic Raw Material, Pharmaceutical Raw Materials , Flavors & Fragrances, Health Care Material, Herbal Extract

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The information of 2bvideo.com limited shown above is provided by the user or collected on the network. Video 2B does not guarantee the authenticity,accuracy and legitimacy of 2bvideo.com limited information. Video 2B does not involve legal relationships and disputes between users arising from transactions other than secured transactions on this website. Disputes shall be settled by you through negotiation. If you are the person in charge or relevant employee of this enterprise, if you find that the enterprise information is incorrect or want to manage thiscompany, please contact us jacklee1558@gmail.com, after you claim the enterprise, you can obtain management permission, publish supplyand demand information, bring consulting orders, and remove page advertisements.
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