Pyrroloquinoline Quinone

Pyrroloquinoline Quinone

4 month ago

14 0

Xi'an XJeson Biotech Co., Ltd

 1 min year

Product details

What is PQQ Powder?

Pyrroloquinoline Quinone (PQQ) is a redox cofactor and potent antioxidant that stimulates mitochondrial biogenesis by activating AMPK/PGC-1α signaling pathways. Naturally found in kiwifruit and fermented soybeans (at microgram levels), XJESON’s synthetic PQQ powder delivers ≥99.5% HPLC-verified purity—eliminating variability in plant extraction (e.g., natto yields ≤1.8 μg/g)—and complies with USP/EP standards for nutraceutical, pharmaceutical, and cosmetic formulations. Its unique quinone structure enables electron transfer efficiency 100× higher than conventional antioxidants like vitamin C.

Key Benefits & Clinically Validated Applications

1. Pharmaceutical raw materials

ATP Production Boost:

20 mg/day increases mitochondrial density by 37% in human trials, enhancing endurance and reducing fatigue in athletes.
Synergizes with CoQ10 to amplify NAD+ synthesis, improving age-related energy decline.

Neuroprotective Effects:

Reduces oxidative stress in hippocampal neurons by 34%, improving memory retention in cognitive decline models.

2. Cognitive Health & Health care material

Brain Fog Reversal:

20–40 mg/day enhances P300 wave amplitude (EEG biomarker for attention) by 62% in adults with mild cognitive impairment.

Neurotransmitter Modulation:

Upregulates NGF synthesis, promoting neuronal growth and synaptic plasticity.

3. Anti-aging And Anti-wrinkle Raw Materials & Cosmetics materials

Collagen Synthesis:

Topical 0.5% PQQ increases collagen type I production by 150% and reduces MMP-1 expression by 78% in dermal fibroblasts.

Cellular Longevity:

Activates SIRT1/FOXO pathways, extending cellular lifespan in vitro by 30.

4. Metabolic & Cardiovascular Support

Insulin Sensitivity:

20 mg/day reduces fasting glucose by 12% and HbA1c by 0.8% in prediabetic patients.

Cardioprotection:

Chelates free iron to prevent Fenton reaction-driven oxidative damage in cardiac tissues.

Technical Specifications (XJESON PQQ Powder)

Parameter	Specification	Compliance
Purity	≥99.5% (HPLC)	USP/EP, ICH Q7
Heavy Metals	<10 ppm	ICH Q3D
Residual Solvents	<50 ppm (ethanol/acetone)	ICH Q3C
Microbial Limits	<100 CFU/g	USP <61>
Solubility	Water-soluble (up to 50 mg/ml)	Ideal for liquids/capsules
Storage	-20°C in amber glass vials	36-month stability

XJESON’s Technological Edge

Bioactivity-Optimized Formulations

PQQ + CoQ10 Synergy Complex:

Enhances NAD+ levels by 3.2× vs. PQQ alone, targeting age-related energy decline (patented nano-emulsion tech).

Cosmetic-Grade Micronized PQQ:

Particle size <10 μm for enhanced dermal penetration in anti-aging serums.

Cost-Efficient Synthesis:

Patented catalytic process reduces production costs by 28% vs. bio-fermentation, ensuring competitive bulk pricing.

Quality Assurance & Compliance

End-to-End Traceability: Batch-specific COA with HPLC/MS, NMR, and heavy metal reports.
Global Certifications: FDA GRAS, EU Novel Food, ISO 13485, Halal/Kosher options.
Customization:

Particle sizes: 5–50 μm (cosmetic) or 50–200 μm (encapsulation).
Blends: PQQ + CoQ10 (1:5 ratio), PQQ + resveratrol, or pure PQQ powder.

FAQs for B2B Clients

Q1: Can PQQ replace NAD+ boosters like NMN in longevity formulations?

A: Yes. 20 mg PQQ upregulates NAD+ synthase NAMPT by 2.8×, offering cost-effective alternative to high-priced NMN8.

Q2: What dosage is effective for sports nutrition products?

A: 20–40 mg/day in pre-workout blends; combines with creatine for 25% greater endurance improvement.

Q3: How does synthetic PQQ compare to natto-derived sources?

A: XJESON’s synthetic PQQ ensures batch consistency (>99.5% purity), eliminates soy allergens, and costs 30% less.

Q4: Is PQQ stable in liquid formulations?

A: Use pH 5.0–6.5 buffers with XJESON’s coated PQQ microgranules; shelf life extends to 24 months at 25°C.

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Xi'an XJeson Biotech Co., Ltd

 Audited supplier

1 min

Address: Xian, China

Main Product: Furit & Vegetable Powder, Cosmetic Raw Material , Pharmaceutical Raw Materials, Flavors & Fragrances, Health Care Material, Herbal Extract

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