
The anti wrinkle mechanism of Acetyl Octapeptide-3
The core anti wrinkle mechanism of acetyloctapeptide-3 is based on its inhibitory effect on the release of neurotransmitter acetylcholine (ACh). Research has found that this peptide competitively binds to the SNARE protein complex (such as SNAP-25) on the presynaptic membrane, blocking the fusion process between vesicles and the cell membrane, thereby inhibiting the release of acetylcholine into the synaptic cleft (reference 2). This effect can reduce the transmission of muscle contraction signals, reduce the amplitude of facial expression muscle movement by 20% -30% (Reference 3), and ultimately alleviate dynamic wrinkles such as crow's feet and forehead wrinkles caused by repeated expression movements.
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