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Palmitoyl Pentapeptide-4 cas:214047-00-4 is a synthetic signal peptide composed of palmitic acid and five amino acids. Its INCI name is "Palmitoyl Pentapeptide-4" and it is included in the Chinese "Catalogue of Used Cosmetic Raw Materials". It simulates the natural repair mechanism of the skin, stimulates collagen production, and is widely used in anti-aging skincare products, focusing on wrinkle removal, firming, and repair effects. Mechanism of Palmitoyl Pentapeptide-4:Palmitoyl pentapeptide-4 promotes the synthesis of collagen types I, III, and IV by activating dermal fibroblasts (Lintner, 2000). Type I collagen enhances skin support, type III improves elasticity, and type IV participates in basement membrane repair, collectively reducing wrinkle depth. In addition, it can upregulate the expression of fibronectin (a key component of extracellular matrix) and polysaccharides (such as hyaluronic acid) (Zhang et al., 2015), enhance skin water locking ability, and accelerate the activity of wound repair genes (such as TGF - β) (Gorouhi&Maibach, 2009), thereby improving fine lines and sagging.
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