Urolithin A is a defined small-molecule compound with CAS number 1143-70-0. Commercial material can be produced through synthetic or bioconversion-based processes and is generally supplied as a white to light beige crystalline powder.
High-purity Urolithin A is commonly specified at 98%–99%, with HPLC used for purity determination. Additional quality-control parameters may include moisture, ash, heavy metals, and microbiological testing. Batch documentation can include a Certificate of Analysis and Safety Data Sheet.
Urolithin A is investigated for its relationship with mitochondrial quality-control pathways, including mitophagy. It is used in dietary supplement and sports nutrition product development and is also studied in cellular research models. Selected grades may be evaluated for cosmetic and skincare formulations according to applicable regulatory requirements.

| Item | Specification |
|---|---|
| Product Name | Urolithin A |
| CAS Number | 1143-70-0 |
| Product Type | Synthetic or bioconversion-derived material |
| Physical Form | Crystalline powder |
| Appearance | White to light beige crystalline powder |
| Typical Purity | 98%–99% |
| Main Analytical Method | HPLC |
| Additional Testing | Moisture, ash, heavy metals, microbiological testing |
| Solubility Characteristic | Limited water solubility |
| Formulation Formats | Capsules, tablets, blended powders, cosmetic formulations |
| Research Application | In vitro cellular research |
| Documentation | COA and SDS available |
Urolithin A is a poorly water-soluble compound, making solubility and dispersion important considerations during formulation development. Direct incorporation into dry capsules or tablets differs technically from developing aqueous or dispersed systems.
For solid dietary supplement formulations, particle distribution, excipient compatibility, content uniformity, and processing conditions should be considered. In blended powders, adequate mixing is important for maintaining consistent distribution of the ingredient throughout the finished formulation.
Where improved aqueous dispersion is required, formulation approaches such as cyclodextrin inclusion may be evaluated. The effectiveness of such modification depends on the cyclodextrin type, loading ratio, manufacturing process, and final dosage form. Any modified system should be characterized independently rather than assuming that the properties of the untreated crystalline powder remain unchanged.
Purity by HPLC provides a primary basis for material standardization, while contaminant and microbiological testing supports broader quality assessment.

In dietary supplement development, Urolithin A can be incorporated into capsules, tablets, and multi-ingredient powder systems. It has attracted research interest in relation to mitochondrial function and mitophagy, particularly within healthy-aging and cellular-energy research.
Sports nutrition represents another formulation context where Urolithin A may be considered. Finished-product design should account for ingredient concentration, serving format, compatibility with other components, and applicable regulatory requirements.
For skincare development, suitable grades may be evaluated in formulations focused on aging-related skin research and conditioning. Because cosmetic formulations frequently contain complex water and oil phases, solubility, dispersion, ingredient interactions, and finished-product stability require formulation-specific testing.
Urolithin A is also used as a research material in in vitro cellular experiments. Research-grade requirements may differ from those for commercial dietary supplement or cosmetic ingredients, so purity, documentation, and intended-use specifications should be evaluated separately.
Commercial Urolithin A powder is typically standardized according to chromatographic purity. Grades specified at 98%–99% should be accompanied by an analytical method that clearly defines how purity is determined.
Routine quality evaluation may include:
A COA can document batch-specific analytical results, while an SDS provides information relevant to material handling and storage. Buyers should compare analytical methods, specification limits, production route, and intended application when evaluating different Urolithin A grades.
Because the material has limited water solubility, formulation requirements should be established before selecting a standard crystalline powder or a modified delivery system. The powder should be stored in tightly sealed packaging under suitable dry conditions and protected from excessive heat and direct light.
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